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PIPELINE

Creating Transformative Solutions for Patients

Superior Pharmacokinetics Profile

INR301 is a novel, next-generation anti-PD-L1 antibody designed to penetrate the blood-brain barrier with high brain bioavailability without diminishing the systemic exposure.​

Brain PK profiles in AD mice​

Biomarkers in the subiculum of AD mice at 1 month after single IV injection

Plasma PK profiles in AD mice​

Biomarkers in the subiculum of AD mice at 1 month after single IV injection

Brain and plasma PK profiles of control antibody
and INR301 at various time points in AD mice.

Superior Efficacy Profile

우리의 다중모달 접근법은 알츠하이머 병 환자의 뇌에서 면역관문 체계를 조절하여 반응성 신경교세포 지표인 GFAP(Glial Fibrillary Acidic Protein), 아밀로이드 베타 플라크, 그리고 인산화된 타우 단백질을 유의미하게 감소시킵니다.

Biomarkers in the subiculum of AD mice at 1 month after single IV injection

Biomarkers in the subiculum of AD mice at 1 month after single IV injection

Click for graph

Biomarkers in the subiculum of AD mice at 1 month after single IV injection
Biomarkers in the subiculum of AD mice at 1 month after single IV injection
Biomarkers in the subiculum of AD mice at 1 month after single IV injection
Biomarkers in the subiculum of AD mice at 1 month after single IV injection

Mode of Action

뇌의 만성적이고 불균형한 염증 반응으로 인한 면역조절장애가 알츠하이머병의 병태생리학적 원인으로 주목받고 있습니다. 뇌 면역관문체계인 PD-1/PD-L1의 조절을 통해 성상세포, 미세아교세포, 신경세포간의 면역 상호작용을 재프로그래밍하는 새로운 치료 접근법이 제시되고 있습니다. INR301은 뇌 내 면역 균형을 회복함으로써 알츠하이머병에 대한 혁신적인 치료 패러다임을 제시하는 퍼스트인클래스 뇌혈관장벽 투과 항-PD-L1 항체입니다.

INR301 treatment

INR301 treatment

Click for immunostaining

Alzheimer's disease

Alzheimer's disease

Click for immunostaining

INR301 targets PD-L1+ reactive astrocyte in the brain of AD mice​

INR301 targets PD-L1+ reactive astrocyte in the brain of AD mice​

PD-1 and PD-L1 interaction in the brain of AD mice​

PD-1 and PD-L1 interaction in the brain of AD mice​

INR301 treatment

INR301 treatment

Click for immunostaining

Alzheimer's disease

Alzheimer's disease

Click for immunostaining

INR301 targets PD-L1+ reactive astrocyte in the brain of AD mice​

INR301 targets PD-L1+ reactive astrocyte in the brain of AD mice​

PD-1 and PD-L1 interaction in the brain of AD mice​

PD-1 and PD-L1 interaction in the brain of AD mice​

Discovery

Pre-Clinical

Early Clinical

Late Clinical

Candidate

Target

Indication

INR303

비공개

퇴행성 뇌질환

INR302

비공개

알츠하이머병

INR301

PD-L1

알츠하이머병

TRANSMAB® Technology ​

Candidate
Target
Indication
Discovery
Pre-Clinical
Early Clinical
Late Clinical
INR301
PD-L1
알츠하이머병
INR302
비공개
알츠하이머병
INR303
비공개
퇴행성 뇌질환
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